| Product Name | Paip2b Antibody (E-13) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping within an internal region of Paip2b of human origin |
| Modification Notes | Various PABP-interacting proteins bind to and regulate the activity of polyadenylate-binding protein (PABP), an essential, well-conserved, multifunctional protein involved in translational initiation, mRNA biogenesis and degradation. PABP enhances translation by circularizing mRNA through its interaction with the translation initiation factor eIF4G and mRNA's poly(A) tail. PABP-interacting proteins include PaiP1, a translational stimulator, and Paip2a and Paip2b, translational inhibitors. Paip1 is thought to act as a translational activator in 5' cap-dependent translation by interacting with PABP and the initiation factors eIF4A and eIF3, whereas Paip2 decreases the affinity of PABP for polyadenylate RNA, and disrupts the repeating structure of poly(A) ribonucleoprotein. Paip2b (poly(A) binding protein interacting protein 2B) is a 123 amino acid protein that may be involved in regulating PABP activity. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFELISA |
| recommended for detection of Paip2b of mouse, rat and human origin by WB, IF and ELISA non cross-reactive with Paip2: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an internal region of Paip2b of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an internal region of Paip2b of human origin |
| Entrez Gene | 400961 |
|---|
| Application Notes | recommended for detection of Paip2b of mouse, rat and human origin by WB, IF and ELISA non cross-reactive with Paip2: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
