Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human cerebellum tissue showing cytoplasmic staining of Purkinje cells and cytoplasmic and nuclear staining of cells in granular layer and cells in molecular layer.Application
Western blot analysis of SOCS-7 expression in IL-6-treated HeLa (A), MCF7 (B), IFN-γ-treated HL-60 (C), Raji (D) and IL-2-treated Jurkat (E) whole cell lysates.Application
Western blot analysis of human recombinant SOCS-7 fusion protein.| Product Name | SOCS-7 Antibody (H-112) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 73-184 mapping near the N-terminus of SOCS-7 of human origin |
| Modification Notes | The SOCS (suppressor of cytokine signaling) gene family consists of a group of proteins that negatively regulate cytokine signal transduction (1). The SOCS family proteins contain a central SH2 domain and a carboxy-terminal region termed the “SOCS box.” The SOCS-1 (also called SSI-1 and JAB), SOCS-2 (also called SSI-2 and CIS2) and SOC-3 (also called SSI-3 and CIS3) genes are known to be upregulated by IL-6 and other cytokines (2). SOCS-4, SOCS-5, SOCS-6 and SOCS-7 were identified by their sequence homology with the SOCS box (3). CIS (cytokine-inducible SH2-containing protein) is also a member of the SOCS family (4,5). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of SOCS-7 of mouse, rat and human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 73-184 mapping near the N-terminus of SOCS-7 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 73-184 mapping near the N-terminus of SOCS-7 of human origin |
| Entrez Gene | 30837 |
|---|
Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human cerebellum tissue showing cytoplasmic staining of Purkinje cells and cytoplasmic and nuclear staining of cells in granular layer and cells in molecular layer.
Application
Western blot analysis of SOCS-7 expression in IL-6-treated HeLa (A), MCF7 (B), IFN-γ-treated HL-60 (C), Raji (D) and IL-2-treated Jurkat (E) whole cell lysates.
Application
Western blot analysis of human recombinant SOCS-7 fusion protein.| Application Notes | recommended for detection of SOCS-7 of mouse, rat and human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
