| Modification Notes |
ADAL (adenosine deaminase-like) is a 355 amino acid protein belonging to the adenosine and AMP deaminases family. Encoded by a gene that maps to human chromosome 15q15.3, ADAL exists as two alternatively spliced isoforms and may share the same catalytic function as adenosine deaminase. ADAL operates as a hydrolase and participates in adenosine deaminase activities, nucleotide metabolism and purine ribonucleoside monophosphate biosynthetic processes. ADAL is down-regulated in RNA in the presence of human T-cell leukemia virus type 1 (HTLV-I) p30. ADAL homologs exist for insects, vertebrates and most fungi, but not in prokaryotes, suggesting ADAL was acquired on the lineage leading to extant eukaryotes. |