| Product Name | GEMC1 Antibody (V-16) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | raised against a peptide mapping within an internal region of GEMC1 of human origin (Accession/GI: 88966042) |
| Modification Notes | GEMC1 (geminin coiled-coil domain-containing protein 1) is a 334 amino acid nuclear protein that regulates DNA replication by promoting the recruitment of Cdc45 onto replication origins. A member of the GEMC1 family, GEMC1 is highly phosphorylated and interacts with chromatin during formation of the pre-replication complex. The gene encoding GEMC1 maps to human chromosome 3, which is made up of about 214 million bases encoding over 1,100 genes. Notably, there is a chemokine receptor gene cluster and a variety of human cancer related loci on chromosome 3. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells. Key tumor suppressing genes on chromosome 3 encode apoptosis mediator RASSF1, cell migration regulator HYAL1 and angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFELISA |
| recommended for detection of GEMC1 of human origin by WB, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | raised against a peptide mapping within an internal region of GEMC1 of human origin (Accession/GI: 88966042) |
|---|---|
| Tissue Specificity | raised against a peptide mapping within an internal region of GEMC1 of human origin (Accession/GI: 88966042) |
| Entrez Gene | 647309 |
|---|
| Application Notes | recommended for detection of GEMC1 of human origin by WB, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
