Application
Western blot analysis of FRG1 expression in HeLa (A) and Jurkat (B) nuclear extracts.| Product Name | FRG1 Antibody (FL-258) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-258 representing full length FRG1 of human origin |
| Conjugation | Agarose |
| Modification | Acetylated |
| Modification Notes | FRG1 is a 258 amino acid nuclear protein encoded by the human gene FRG1. The FRG1 protein is thought to be involved in pre-messenger RNA splicing. FRG1 plays a role in processing pre-rRNA, assembling rRNA into ribosomal subunits and may also be involved in pre-mRNA splicing. Facioscapulohu-meral muscular dystrophy (FSHD) is a disease state associated with internal deletions among the tandem array of D4Z4 repeats on chromosome 4q35, a subtelomere region of chromosome 4 that contains the FRG1 gene. The muscle degeneration that is common in patients with FSHD results from increased expression of genes proximal to the deletion, including FRG1. In addition to muscle degeneration, most FSHD patients also develop abnormalities of the retinal vasculature. FRG1 is expressed in adult and fetal muscle, lymphocytes and placenta. It can be localized to nuclear Cajal bodies or speckles. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIFIHCIPWB |
| WB:1:100~1:400 IP:1:20~1:100 IF:1:20~1:100 IHC:1:10~1:50 |
|
| Species Reactivity | HumanMouseRat |
| Predicted Reactivity | equine, canine, bovine and porcine |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-258 representing full length FRG1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-258 representing full length FRG1 of human origin |
| Entrez Gene | 2483 |
|---|
Application
Western blot analysis of FRG1 expression in HeLa (A) and Jurkat (B) nuclear extracts.| Application Notes | WB:1:100~1:400 IP:1:20~1:100 IF:1:20~1:100 IHC:1:10~1:50 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
