Application
Antibodies tested include RAR (M-454): (A) and RARγ (C-19): (B).Application
Antibodies tested include RARγ (C-19): (A) and RARγ (G-1): (B).| Product Name | RARγ Antibody (C-19) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping at the C-terminus of RARγ of human origin |
| Modification Notes | Retinoids are metabolites of vitamin A (retinol) that are important signaling molecules during vertebrate development and tissue differentiation. Retinoic acid receptors (RARs) and retinoid X receptors (RXRs) are nuclear transcription factors that modulate the effects of retinoids (RA) on gene expression. Most retinoid forms (including all trans RA, 9-cis RA, 4oxo RA and 3,4 dihydro RA) activate RAR family members, whereas RXR family members are activated by 9-cis-RA only. RA binds RARs, inducing a change in receptor configuration that allows DNA binding and increased gene transcription from specific genes to occur. RAR family members, which include RARå, RAR∫ and RAR©, belong to the same class of nuclear transcription factors as thyroid hormone receptors, vitamin D3 receptor and ecdysone receptor. Retinoid receptor expression is tissue specific; the skin expresses RAR© and RXRå. The expression of RAR© and RXR∫ was somewhat decreased in lung cancers. The human RAR© gene maps to chromosome 12q13. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISAGSChIP |
| recommended for detection of RARγ1 and RARγ2 of human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping at the C-terminus of RAR&gamma of human origin |
|---|---|
| Tissue Specificity | epitope mapping at the C-terminus of RARγ of human origin |
| Entrez Gene | 5916 |
|---|
Application
Antibodies tested include RAR (M-454): (A) and RARγ (C-19): (B).
Application
Antibodies tested include RARγ (C-19): (A) and RARγ (G-1): (B).| Application Notes | recommended for detection of RARγ1 and RARγ2 of human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
