| Modification Notes |
Growth arrest specific proteins, including Gas 1 and Gas 6, are activated in quiescent cells. Gas 1-induced growth arrest is mediated by p53, and Gas 1 appears to be able to suppress tumor cell growth. Gas 6, a ligand for the tyrosine kinase receptor Axl, was initially identified as a member of the vitamin K-dependent protein family and exhibits a high degree of amino acid sequence homology to protein S, a negative co-regulator in the coagulation pathway. |