| Modification Notes |
Isoamyl acetate is sythesized from isoamyl alcohol and acetyl coenzyme A in Saccharomyces cerevisiae with the assistance of alcohol acetyltransferase (AATFase). IAH1 (Isoamyl acetate-hydrolyzing esterase 1 homolog) is a 248 amino acid protein that belongs to the 'GDSL' lipolytic enzyme family and IAH1 subfamily. IAH1 is a probable lipase and is an import component in the fermentation process of alcohol. The gene encoding IAH1 maps to human chromosome 2p25.1 and mouse chromosome 12 A1.3; overexpression of the IAH1 gene may lead to decreased levels of ethyl acetate, isoamyl acetate, hexyl acetate and 2-phenylethyl acetate. Human chromosome 2 consists of 237 million bases, encodes over 1,400 genes and makes up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2 including Harlequin icthyosis, sitosterolemia and Alström syndrome. |