| Product Name | 17β-HSD3 Antibody (M-125) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 181-305 mapping at the C-terminus of 17β-HSD3 of mouse origin |
| Modification Notes | 17∫-HSD3 (17∫ hydroxysteroid dehydrogenase type 3) belongs to the 17∫-HSD family of proteins that regulate the availability of steroids within various tissues throughout the body. 17∫-HSD3 is expressed predominantly in the testis. It is an NADPH-dependent, membrane-bound enzyme. 17∫-HSD3 converts inactive steroids to their active form through its reductive activity. More specifically,17∫-HSD3 catalyzes the conversion of androstenedione to testosterone in the testis. The production of testosterone is necessary for male sex differentiation. Mutations in the gene that encodes this protein can result in an autosomal recessive male to female sex reversal. A deficiency of 17∫-HSD3 results in a defect in the biosynthesis of testosterone. 17∫-HSD3 inhibitors include 1,4-androstadiene-1,6,17-trione, androsterone 3∫-substituted derivatives, glycyrrhizin, glycyrrhetinic acid, losulazine, amphetamine, methotrexate and S-petasine. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of 17β-HSD3 of mouse and rat origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 181-305 mapping at the C-terminus of 17&beta -HSD3 of mouse origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 181-305 mapping at the C-terminus of 17β-HSD3 of mouse origin |
| Application Notes | recommended for detection of 17β-HSD3 of mouse and rat origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
