Application
Western blot analysis of LASS4 expression in HeLa (A), SK-MEL-28 (B) and U-698-M (C) whole cell lysates.| Product Name | LASS4 Antibody (H-69) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 326-394 mapping at the C-terminus of LASS4 of human origin |
| Modification Notes | The LASS (longevity assurance homolog) family members are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1, LASS2, LASS3, LASS4, LASS5 and LASS6) and they are all involved in sphingolipid synthesis. LASS4 is a 394 amino acid endoplasmic reticulum, multi-pass membrane protein. LASS4 increases the levels of long ceramides such as C22:0- and C24:0-ceramides. In cells deficient for CLN9, as observed in neuronal ceroid lipofuscinosis (NCL) or Batten disease, LASS4 can increase ceramide levels and partially correct growth and apoptosis. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of LASS4 of human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 326-394 mapping at the C-terminus of LASS4 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 326-394 mapping at the C-terminus of LASS4 of human origin |
| Entrez Gene | 79603 |
|---|
Application
Western blot analysis of LASS4 expression in HeLa (A), SK-MEL-28 (B) and U-698-M (C) whole cell lysates.| Application Notes | recommended for detection of LASS4 of human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
