| Product Name | SCO1 Antibody (H-66) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 178-243 mapping near the C-terminus of SCO1 of human origin |
| Modification Notes | The SCO1 and SCO2 protein homologs belong to the SCO1/2 family of proteins. SCO1 and SCO2 both localize to the mitochondrion and are inner membrane proteins crucial for copper insertion or transport to the active site of cytochrome c oxidase (COX). COX is a crucial component in energy production because it functions as the terminal enzyme in the respiratory chain. SCO1 is predominantly expressed in highly oxidative phosphorylation tissues such as brain, heart and muscle, while SCO2 is ubiquitously expressed. Defects in the gene encoding for SCO1 may cause cytochrome c oxidase deficiency, a hetero-genous disorder. Defects in the gene encoding for SCO2 may cause cardioencephalomyopathy with cytochrome c oxidase deficiency, a fatal infantile disorder characterized by hypertrophic cardiomyopathy, lactic acidosis and gliosis. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of SCO1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 178-243 mapping near the C-terminus of SCO1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 178-243 mapping near the C-terminus of SCO1 of human origin |
| Entrez Gene | 6341 |
|---|
| Application Notes | recommended for detection of SCO1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
