| Product Name | WIPI-1 Antibody (H-95) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 352-446 mapping at the C-terminus of WIPI-1 of human origin |
| Modification Notes | WIPI-1 (WD repeat domain, phosphoinositide interacting-1), also known as WIPI1, ATG18 or WIPI49, is a 446 amino acid protein that localizes to cytoplasmic vesicles, endosomes, clathrin-coated vesicles and the trans-Golgi network. Ubiquitously expressed with highest expression in heart, testis, placenta, pancreas and skeletal muscle, WIPI-1 is thought to play a role in autophagy and may regulate protein trafficking in certain recycling pathways. In addition, WIPI-1 interacts with androgen and estrogen receptors (ARs and ERs, respectively) and, through this interaction, may modify receptor function. WIPI-1 contains three WD repeats and has a 7-bladed propeller structure with a conserved motif that facilitates its interaction with other proteins. WIPI-1 is expressed as two isoforms, designated alpha and beta, and its expression is upregulated in a variety of tumors, suggesting a role in carcinogenesis. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of WIPI-1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 352-446 mapping at the C-terminus of WIPI-1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 352-446 mapping at the C-terminus of WIPI-1 of human origin |
| Entrez Gene | 55062 |
|---|
| Application Notes | recommended for detection of WIPI-1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
