Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human ovary tissue showing cytoplasmic staining of ovarian stroma cells.| Product Name | TMEM16F Antibody (G-14) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping within an extracellular domain of TMEM16F of human origin |
| Modification Notes | TMEM16F (transmembrane protein 16F), also known as ANO6 (anoctamin 6), is a 910 amino acid multi-pass membrane protein that is expressed in retinal tissue, embryonic stem cells and fetal liver, as well as in intestinal cancer and chronic myologenous leukemia. Due to its expression in cancerous tissues, TMEM16F may be involved in tumorigenesis. The gene encoding TMEM16F maps to chromosome 12. Encoding over 1,100 genes within 132 million bases, chromosome 12 makes up about 4.5% of the human genome. A number of skeletal deformities are linked to chromosome 12, including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Noonan syndrome, which is characterized by heart and facial developmental defects, is caused by a mutant form of the PTPN11 gene product, SH-PTP2. Chromosome 12 is also home to a homeobox gene cluster which encodes crucial transcription factors for morphogenesis, and the natural killer complex gene cluster encoding C-type lectin proteins which mediate the NK cell response to MHC I interaction. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFIHCELISA |
| recommended for detection of TMEM16F of mouse, rat and human origin by WB, IF, IHC(P) and ELISA non cross-reactive with other TMEM16 family members also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an extracellular domain of TMEM16F of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an extracellular domain of TMEM16F of human origin |
| Entrez Gene | 196527 |
|---|
Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human ovary tissue showing cytoplasmic staining of ovarian stroma cells.| Application Notes | recommended for detection of TMEM16F of mouse, rat and human origin by WB, IF, IHC(P) and ELISA non cross-reactive with other TMEM16 family members also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
