| Product Name | Bcl-9L Antibody (H-225) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-225 mapping at the N-terminal of Bcl-9L of human origin |
| Modification Notes | Bcl-9L (B-cell CLL/lymphoma 9-like), also known as DLNB11, is a 1,499 amino acid protein that localizes to the nucleus and contains a specialized C-terminal domain that is important for its overall activity. Expressed in breast tissue, as well as in eye, lung, prostate and various carcinomas, Bcl-9L functions as a transcriptional activator that forms a complex with Parafibromin and ∫-catenin and is thought promote the transcriptional activity of Parafibromin and enhance the neoplastic transforming activity of ∫-catenin. Bcl-9L exists as multiple alternatively spliced isoforms and is thought to be involved in tumorigenesis, possibly playing a role in tumor transformation and metastasis. The gene encoding Bcl-9L maps to human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that maps to chromosome 11. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Bcl-9L of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine bovine and feline: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-225 mapping at the N-terminal of Bcl-9L of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-225 mapping at the N-terminal of Bcl-9L of human origin |
| Entrez Gene | 283149 |
|---|
| Application Notes | recommended for detection of Bcl-9L of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine bovine and feline: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
