Application
Western blot analysis of AGXT2L2 expression in non-transfected (A) and human AGXT2L2 transfected (B) CMV whole cell lysates.Application
Western blot analysis of AGXT2L2 expression in mouse lung (A) and mouse thymus (B) tissue extracts and LADMAC (C) and KNRK (D) whole cell lysates.| Product Name | AGXT2L2 Antibody (H-70) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 381-450 mapping at the C-terminus of AGXT2L2 of human origin |
| Modification Notes | Members of the class-III pyridoxal-phosphate-dependent aminotransferase family, such as AGXT2, catalyze the conversion of glyoxylate to glycine using L-alanine as the amino donor. AGXT2 protects from asymmetric dimethylarginine (ADMA)-induced inhibition in nitric oxide (NO) production. Elevated blood concentrations of ADMA, a methyl derivate of the amino acid arginine and an endogenous inhibitor of nitric oxide (NO) synthase, is produced by the physiological degradation of methylated proteins and is found in association with diabetes, hypertension, congestive heart failure and atherosclerosis. AGXT2L2 (alanine-glyoxylate aminotransferase 2-like 2) is a 450 amino acid pyridoxal phosphate that exists as a homotetramer. Belonging to the class-III pyridoxal-phosphate-dependent aminotransferase family, AGXT2L2 localizes to the mitochondria and exists as three alternatively spliced isoforms. Encoded by a gene located on human chromosome 5q35.3, AGXT2L2 may have similar functions as AGXT2. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of AGXT2L2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and bovine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 381-450 mapping at the C-terminus of AGXT2L2 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 381-450 mapping at the C-terminus of AGXT2L2 of human origin |
Application
Western blot analysis of AGXT2L2 expression in non-transfected (A) and human AGXT2L2 transfected (B) CMV whole cell lysates.
Application
Western blot analysis of AGXT2L2 expression in mouse lung (A) and mouse thymus (B) tissue extracts and LADMAC (C) and KNRK (D) whole cell lysates.| Application Notes | recommended for detection of AGXT2L2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and bovine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
