| Product Name | DRR1 Antibody (N-17) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping at the N-terminus of DRR1 of human origin |
| Modification Notes | The chromosomal band of 3p21 is frequently deleted in several types of tumors, suggesting that this region may harbor multiple tumor suppressor genes. The DRR1 (down-regulated in renal cell carcinoma 1) gene, also known as FAM107A and Protein TU3A, is located in this critical chromosomal region and encodes a 144 amino acid nuclear protein that contains a coiled region, suggesting that the protein may function to regulate gene transcription and signal transduction. With the exception of peripheral blood cells, DRR1 is expressed in all normal tissues, but shows significant loss of expression in renal cell carcinomas and frequent loss of expression in cervical, gastric, ovarian and nonsmall cell lung cancers. Transfection of DRR1 mRNA into cancer cell lines inhibits cell growth and proliferation, supporting the evidence that the gene functions as an important tumor suppressor. There are two isoforms of DRR1 that exist as a result of alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFELISA |
| recommended for detection of DRR1 of mouse, rat and human origin by WB, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping at the N-terminus of DRR1 of human origin |
|---|---|
| Tissue Specificity | epitope mapping at the N-terminus of DRR1 of human origin |
| Entrez Gene | 11170 |
|---|
| Application Notes | recommended for detection of DRR1 of mouse, rat and human origin by WB, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
