| Modification Notes |
SLC35F5 (Solute carrier family 35 member F5), also known as Hepatitis C virus NS5A-transactivated protein 3, is a 523 amino acid multi-pass membrane protein that belongs to the SLC35F solute transporter family. Existing as two alternatively spliced isoforms, SLC35F5 functions as a putative solute transporter. The gene encoding SLC35F5 maps to human chromosome 2, which houses over 1,400 genes and comprises nearly 8% of the human genome. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the chromosome 2-localized ABCA12 gene, while the lipid metabolic disorder sitosterolemia is associated with defects in the ABCG5 and ABCG8 genes, which also map to chromosome 2. |