| Product Name | LOXHD1 Antibody (N-20) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping near the N-terminus of LOXHD1 of human origin |
| Modification Notes | Lipoxygenases are a family of enzymes which dioxygenate unsaturated fatty acids, thus initiating lipoperoxidation of membranes, the synthesis of signaling molecules, as well as inducing structural and metabolic changes in the cell. The Lox enzymes in mammals include 12-LO and 15-LO, which are classified with respect to their positional specificity of the deoxygenation of their most common substrate, arachidonic acid. The 12-LO pathway is a regulator of cell survival and apoptosis and also affects the expression and localization of the Integrin åV/∫5 and actin microfilaments in rat Walker 256 carcinosarcoma cells. 15-LO acts in physiological membrane remodeling and the pathogenesis of atherosclerosis, inflammation, and carcinogenesis. Related to the LOX enzymes, LOXHD1 (lipoxygenase homology domain-containing protein 1) is a 1947 amino acid protein that contains 14 PLAT domains. There are five isoforms of LOXHD1 that are produced as a result of alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFELISA |
| recommended for detection of LOXHD1 of human origin by WB, IF and ELISA non cross-reactive with isoforms LOXHD1-3, LOXHD1-4 or LOXHD1-5 also reactive with additional species, including canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping near the N-terminus of LOXHD1 of human origin |
|---|---|
| Tissue Specificity | epitope mapping near the N-terminus of LOXHD1 of human origin |
| Entrez Gene | 125336 |
|---|
| Application Notes | recommended for detection of LOXHD1 of human origin by WB, IF and ELISA non cross-reactive with isoforms LOXHD1-3, LOXHD1-4 or LOXHD1-5 also reactive with additional species, including canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
