| Product Name | PTP-PEST Antibody (H-130) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 296-425 mapping within an internal region of PTP-PEST of human origin |
| Modification Notes | Protein tyrosine phosphatases (PTPs) and protein tyrosine kinases (PTKs) play an ubiquitous role in the regulation of tyrosine phosphorylation-mediated signaling pathways. Tyrosine-phosphorylated proteins can be dephosphorylated through the action of PTPs, which are likely to play a regulatory role in the control of cellular growth and differentiation. The gene encoding human PTP-PEST maps to chromosome 7q11.23 and encodes a 780 amino acid cytosolic nonreceptor protein. PTP-PEST is expressed abundantly in a wide variety of hemopoietic cell types, including B cells and T cells. PTP-PEST may constitutively associate with several signalling molecules, including Shc, paxillin, Csk and Cas. In addition, PTP-PEST can induce dephosphorylation of Shc, Pyk2, Fak and Cas, and inactivate the Ras pathway. Dephosphorylation of c-Abl by PTP-PEST represents a novel mechanism by which c-Abl activity is regulated. PTP-PEST can also influence cytoskeletal organization by promoting the turnover of focal adhesions required for cell migration, and through regulation of the proline, serine, threonine phosphatase interacting protein (PSTPIP)-mediated cleavage furrow formation or disassembly during normal cell division. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of PTP-PEST of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 296-425 mapping within an internal region of PTP-PEST of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 296-425 mapping within an internal region of PTP-PEST of human origin |
| Entrez Gene | 5782 |
|---|
| Application Notes | recommended for detection of PTP-PEST of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
