| Product Name | TRFP Antibody (H-124) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 32-155 mapping within an internal region of TRFP of human origin |
| Modification Notes | In mammalian cells, transcription is regulated in part by high molecular weight coactivating complexes that mediate signals between transcriptional activators and RNA polymerase (1). These complexes include SMCC (SRB and MED protein cofactor complex), which consists of various subunits that share homology with several components of the yeast transcriptional mediator complexes (2,3). SMCC associates with the RNAPII (RNA polymerase II) holoenzyme through Srb7 and, in turn, enhances gene-specific activation or repression induced by DNA-binding transcription factors (4). Srb7 also interacts with an additional member of the RNAPII holoenzyme, the human homolog of Drosophila TBP-related factor (TRF)-proximal protein (TRFP) (5). TRFP synergistically associates with coactivators, including PC4 (positive coactivator 4) and USA (upstream stimulatory activity) of the RNAPII and SMCC complex, to enhance basal and gene-specific transcription (5,6). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of TRFP of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 32-155 mapping within an internal region of TRFP of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 32-155 mapping within an internal region of TRFP of human origin |
| Entrez Gene | 9477 |
|---|
| Application Notes | recommended for detection of TRFP of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
