Application
Western blot analysis of collectrin expression in non-transfected: (A) and human collectrin transfected: (B) 293T whole cell lysates and mouse kidney tissue extract (C).| Product Name | collectrin Antibody (I-14) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping within a C-terminal cytoplasmic domain of collectrin of human origin |
| Modification Notes | Collectrin, also known as TMEM27 (transmembrane protein 27) or NX17, is a 222 amino acid single-pass type I membrane protein belonging to the TMEM27 family. Collectrin interacts with Snapin to regulate SNARE complex function, which in turn controls insulin exocytosis. Collectrin has been found to stimulate beta cell replication and plays a role in renal amino acid uptake. Localizing to luminal surface and cytoplasm of renal collecting ducts of the cortex and medulla, collectrin is also found in beta cells of pancreatic islets, where its extracellular domain becomes cleaved following translation and is released from the cell membrane. Collectrin exists as a homodimer, undergoes post-translational glycosylation and interacts with XTRP2. The gene encoding collectrin maps to human chromosome Xp22.2. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of collectrin of mouse, rat and human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within a C-terminal cytoplasmic domain of collectrin of human origin |
|---|---|
| Tissue Specificity | epitope mapping within a C-terminal cytoplasmic domain of collectrin of human origin |
| Entrez Gene | 57393 |
|---|
Application
Western blot analysis of collectrin expression in non-transfected: (A) and human collectrin transfected: (B) 293T whole cell lysates and mouse kidney tissue extract (C).| Application Notes | recommended for detection of collectrin of mouse, rat and human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
