| Product Name | IDI1 Antibody (H-66) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 162-227 mapping at the C-terminus of IDI1 of human origin |
| Modification Notes | IDI1 (isopentenyl-diphosphate delta isomerase 1), also known as IPP1 or IPPI1, is a 227 amino acid member of the IPP isomerase type I family and is involved in cholesterol biosynthesis. Localized to the peroxisome, IDI1 catalytically converts isopentenyl diphosphate (IPP) to its electrophilic isomer, dimethylallyl diphosphate (DMAPP). Specifically, IDI1 uses magnesium as a cofactor to catalyze the 1,3-allylic rearrangement of IPP, thus creating DMAPP, a substrate for subsequent reactions that synthesize farnesyl diphosphate and, ultimately, cholesterol. Defects in the gene encoding IDI1 may be associated with peroxisomal deficiency diseases, such as Zellweger syndrome, a congenital disorder caused by a reduction in the number of peroxisomes. Individuals affected with this disorder generally exhibit lack of muscle tone, an enlarged liver, mental retardation and, in some cases, death. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of IDI1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and canine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 162-227 mapping at the C-terminus of IDI1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 162-227 mapping at the C-terminus of IDI1 of human origin |
| Application Notes | recommended for detection of IDI1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and canine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
