| Product Name | PHR1 Antibody (H-225) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-225 mapping at the N-terminus of PHR1 of human origin |
| Modification Notes | Pleckstrin homology domain retinal protein 1 (PHR1), also designated pleckstrin homology domain-containing family B member 1, is a membrane protein that contains a pleckstrin homology (PH) domain at its N-terminus and a 27 amino acid transmembrane segment at its C-terminus, along with several casein kinase II phosphorylation sites and a putative protein kinase C (PKC) phosphorylation site. The full-length mouse and human PHR1 proteins contain 243 amino acid residues and share 94% sequence identity. The presence of two transcription start sites and alternative splicing results in four PHR1 isoforms in both humans and mice. All PHR1 isoforms bind to transducin ∫© subunits, the binding of which is dependent upon the N-terminal 137 residues of full-length PHR1. This suggests that the PH domain (amino acids 21 to 128), which is present in all PHR1 isoforms, mediates binding. PHR1 shows predominant expression in the outer segments of photoreceptor cells, both in rods and cones, as well as in retina and brain tissues. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of PHR1 of mouse, rat and human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-225 mapping at the N-terminus of PHR1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-225 mapping at the N-terminus of PHR1 of human origin |
| Entrez Gene | 58473 |
|---|
| Application Notes | recommended for detection of PHR1 of mouse, rat and human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
