| Product Name | ADPN Antibody (H-291) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 191-481 mapping at the C-terminus of ADPN of human origin |
| Modification Notes | ADPN, a member of the Adiponutrin family, displays lipase activity that is dependent upon the presence of an activated serine residue. D-glucose elicits a 7-fold increase in ADPN mRNA levels, and insulin has a slight effect on ADPN expression in the presence or absence of glucose. The glucose-induced increase in ADPN expression can be reversed by factors known to raise intracellular cAMP. mRNA ADPN levels are negatively correlated with fasting glucose levels and subjects with high ADPN mRNA levels have increased insulin sensitivity, implicating ADPN in obesity and diabetes. ADPN gene expression in humans is highly regulated by changes in energy balance. In mice adipocytes, ADPN parallels the expression of fatty acid synthase (FAS) and Srebp1c, a variant of Srebp1. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Adiponutrin (ADPN) of human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 191-481 mapping at the C-terminus of ADPN of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 191-481 mapping at the C-terminus of ADPN of human origin |
| Entrez Gene | 80339 |
|---|
| Application Notes | recommended for detection of Adiponutrin (ADPN) of human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
