| Modification Notes |
PWP2 (periodic tryptophan protein 2), also known as EHOC-17, is a 919 amino acid protein that is the human homolog of the Saccharomyces cerevisiae periodic Trp 2 protein. Belonging to the WD repeat PWP2 family of proteins, PWP2 contains 14 WD repeats and has over 40% identity to the yeast homolog. PWP2 is localized to the nucleus and is implicated to play a role in early G1 phase of the cell cycle. Essential for cell viability, PWP2 is also thought to be a candidate for various genetic disorders, such as progressive myoclonus epilepsy (EPM1), autoimmune polyglandular disease (APECED) and holoprosencephaly-1 (HPE1). The PWP2 gene maps to chromosome 21q22.3. |