| Product Name | Selenoprotein N Antibody (H-160) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | raised against amino acids 293-452 mapping within an internal region of Selenoprotein N of human origin |
| Modification Notes | Selenium is an essential trace element that is incorporated as selenocysteine into the primary structure of selenoproteins. Nutritional deficiency of selenium decreases selenoprotein concentrations and leads to pathologic conditions. Most of the known selenoproteins are members of the Glutathione peroxidase or iodothyronine deiodinase families. The Selenoprotein N glycoprotein localizes to the endoplasmic reticulum (ER) and contains selenocysteine at its active site. There are two isoforms associated with Selenoprotein N: isoform 1, the full-length transcript; and isoform 2, which lacks exon 3. Seleno-protein N is primarily expressed in skeletal muscle, brain, lung and placenta, but isoform 2 can also be detected in heart and stomach tissues. Mutations in SEPN1, the gene encoding for Selenoprotein, cause multiminicore disease and rigid spine muscular dystrophy. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Selenoprotein N of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | raised against amino acids 293-452 mapping within an internal region of Selenoprotein N of human origin |
|---|---|
| Tissue Specificity | raised against amino acids 293-452 mapping within an internal region of Selenoprotein N of human origin |
| Entrez Gene | 57190 |
|---|
| Application Notes | recommended for detection of Selenoprotein N of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
