| Modification Notes |
Peregrin, also called BRPF1 or BR140, is a 1214 amino acid bromodomain and PHD finger-containing protein. Localized to the nucleus and expressed ubiquitously with the highest levels of expression in testis and spermatogonia, Peregrin is a zinc-finger protein that is thought to be a transcriptional activator. Peregrin contains one C-terminal PWWP domain and, because of its similarity with transcriptional coactivators such as TAF II p250, is thought to be a DNA-binding protein. The gene encoding Peregrin is disrupted in myeloid leukemia, suggesting a possible role in carcinogenesis. Due to alternative splicing, two isoforms of the Peregrin protein exist. |