Application
Western blot analysis of CysLT2 Receptor expression in A-10 (A) and PC-12 (B) whole cell lysates and mouse spleen tissue extract (C).| Product Name | CysLT2 Receptor Antibody (M-42) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 27-65 mapping near the N-terminus of Cysteinyl leukotriene receptor 2 of mouse origin |
| Modification Notes | Cysteinyl leukotriene (CysLTs) induce intracellular calcium mobilization through the binding of two distinct seven-transmembrane, G protein- coupled receptors, designated CysLT1 and CysLT2 receptors, to induce potent bronchoconstriction. Airway smooth muscle and macrophages express both receptor types, and additionally monocytes and eosinophils express CysLT1 receptor, while cardiac Purkinje cells, adrenal medulla, peripheral blood leukocytes and brain also utilize CysLT2 receptor. The effects of the CysLT receptors can be blocked by antagonists, indicating a therapeutic mechanism for the treatment of asthma and allergies. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of CysLT2 Receptor of mouse and rat origin by WB, IP, IF and ELISA also reactive with additional species, including equine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 27-65 mapping near the N-terminus of Cysteinyl leukotriene receptor 2 of mouse origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 27-65 mapping near the N-terminus of Cysteinyl leukotriene receptor 2 of mouse origin |
Application
Western blot analysis of CysLT2 Receptor expression in A-10 (A) and PC-12 (B) whole cell lysates and mouse spleen tissue extract (C).| Application Notes | recommended for detection of CysLT2 Receptor of mouse and rat origin by WB, IP, IF and ELISA also reactive with additional species, including equine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
