| Product Name | MBD5 Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 601-899 mapping within an internal region of MBD5 of human origin |
| Modification Notes | Methylation of DNA contributes to the regulation of gene transcription in both mammalian and invertebrate systems. DNA methylation predominates on cytosine residues that are present in dinucleotide motifs consisting of a 5’ cytosine followed by guanosine (CpG), and it requires the enzymatic activity of DNA methyltransferase, which results in transcriptional repression of the methylated gene. Several proteins have been identified that associate with the methyl-CpG sites, and they include methyl-CpG binding protein-1 (MBD1), MBD2, MBD3, MBD4, MBD5 and MeCP2. MBD5 is a 1494 amino acid protein containing one MBD domain and one PWWP domain. Localized to the nucleus, MBD5 is expressed in skeletal muscle, kidney, heart, kidney, liver, pancreas and placenta. Mutations in the gene that encodes MBD5 have been found to cause mental retardation autosomal dominant type 1 (MRD1), which is characterized by sub-average general intellectual functioning manifested during the developmental period. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of MBD5 of mouse, rat and human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 601-899 mapping within an internal region of MBD5 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 601-899 mapping within an internal region of MBD5 of human origin |
| Entrez Gene | 55777 |
|---|
| Application Notes | recommended for detection of MBD5 of mouse, rat and human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
