| Modification Notes |
The lipase gene family belongs to one of the most robust genetic superfamilies found in living organisms, which includes esterases and thioesterases. Members of the AB hydrolase subfamily include hepatic lipase (HL), endothelial lipase (EL), lipoprotein lipase (LPL), pancreatic lipase (PL), gastric lipase (GL) and the lecithin-cholesterol acyltransferase (LCAT). These family members play a crucial role in the metabolism of lipids. LCAT esterifies cholesterol, which is required for cholesterol transport. LCAT deficiency has been implicated in fish-eye disease, a rare genetic disorder of high density lipoprotein (HDL) metabolism. |