| Product Name | NEIL3 Antibody (H-194) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-194 mapping at the N-terminus of NEIL3 of human origin |
| Modification Notes | NEIL1, NEIL2 and NEIL3 (also known as endonuclease VIII-like 1,2 and 3 or DNA-(apurinic or apyrimidinic site) lyase NEIL 1, 2 and 3) are nuclear proteins involved in the repair of DNA damaged by oxidation. The NEIL proteins belong to the FPG family. They act as DNA glycosylases that can recognize and remove damaged bases, leaving an abasic site. NEIL3, however, lacks the proline resi-due at the N-terminus which acts as the active site residue found in NEIL1 and NEIL2. Thus, reports of NEIL3 DNA glycosylase activity are contradictory. NEIL3 localizes to the nucleus and only demonstrates expression in thymus and testis tissues. The deduced 605 amino acid NEIL3 protein contains both one FPG-type zinc finger and one RanBP2-type zinc finger. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of NEIL3 of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-194 mapping at the N-terminus of NEIL3 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-194 mapping at the N-terminus of NEIL3 of human origin |
| Entrez Gene | 55247 |
|---|
| Application Notes | recommended for detection of NEIL3 of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
