| Modification Notes |
Sialyltransferases are responsible for the transfer of sialic acid, a negatively charged acidic sugar, from its common nucleotide sugar donor to carbohydrate groups of glycoproteins and glycolipids where it then forms sialylglycoconjugates to influence a number of biological processes. Twenty mammalian sialyltransferase family members have been characterized to date. ST8Sia V, also known as ST8SIA5 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5), SIAT8E or ST8SIA5, is a 376 amino acid single-pass type II membrane protein of the Golgi apparatus that is suggested to participate in the synthesis of certain gangliosides. A member of the glycosyltransferase 29 family, ST8Sia V is involved in protein modification and glycosylation, and is expressed in skeletal muscle, heart and brain. |