Application
Western blot analysis of Psf2 expression in rat skeletal muscle tissue extract.| Product Name | Psf2 Antibody (FL-185) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-185 representing full length Psf2 of human origin |
| Modification Notes | Psf2, also known as GINS2 (GINS complex subunit 2), CGI-122, DC5 or HSPC037, is a 185 amino acid protein that localizes to the nucleus and exists as a mammalian homolog of yeast Psf2. Functioning as a component of the heterotrimeric GINS complex, Psf2 binds to single-stranded DNA and plays a crucial role in the initiation of DNA replication, as well as in the progression of DNA replication forks. Psf2 is subject to DNA damage-dependent phosphorylation, probably by ATM or ATR. The gene encoding Psf2 maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Psf2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-185 representing full length Psf2 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-185 representing full length Psf2 of human origin |
| Entrez Gene | 51659 |
|---|
Application
Western blot analysis of Psf2 expression in rat skeletal muscle tissue extract.| Application Notes | recommended for detection of Psf2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
