| Product Name | MTHFD1 Antibody (H-120) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-120 mapping at the N-terminus of MTHFD1 of human origin |
| Modification Notes | Methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) is a 935-amino acid, folate-dependent protein that is responsible for the consecutive interconversion of tetrahydrofolate derivatives which drive the synthesis of purine, methionine, and thymidylate. The cytosolic MRHFD1 contains three subunits, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase, and 10-formyltetrahydrofolate synthetase, each with distinct activities. MTHFD1 functions as a homodimer consisting of two major domains, an N-terminal containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain in the C-terminus. Mutations in the MTHFD1 gene in pregnant women are associated with an increased risk of giving birth to a child with a neural tube defect, along with a possible risk of decreased embryo survival. MTHFD1 also plays a role in migraine development, since folate metabolism is involved in migraine pathophysiology, mainly in migraine with aura. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of MTHFD1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and canine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-120 mapping at the N-terminus of MTHFD1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-120 mapping at the N-terminus of MTHFD1 of human origin |
| Entrez Gene | 4522 |
|---|
| Application Notes | recommended for detection of MTHFD1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and canine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
