Application
Western blot analysis of SNM1B expression in human cervix tissue extract (A) and HOS whole cell lysate (B).Application
Western blot analysis of SNM1B expression in non-transfected: (A) and human SNM1B transfected: (B) 293T whole cell lysates.| Product Name | SNM1B Antibody (P-14) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping within an internal region of SNM1B of human origin |
| Modification Notes | DNA interstrand cross-links (ICLs) pose lethal threats to DNA as they inhibit segregation, replication and transcription. The mechanism of ICL repair is complex but is at least partly conserved between Saccharomyces cerevisiae and mammals. SNM1B (SNM1 homolog B), also known as DCLRE1B (DNA cross-link repair 1B (PSO2 homolog, S. cerevisiae)) or APOLLO, is a 532 amino acid nuclear protein that localizes to discrete foci and is likely required for DNA interstrand cross-link repair. SNM1B assists in the maintenance of telomeres during S-phase and interacts with TRF2 (telomeric repeat binding factor 2), a protein involved in telomeric organization and protection, in the early DNA-damage response. A member of the DNA repair metallo-beta-lactamase (DRMBL) family, SNM1B becomes phosphorylated following translation, either by ATM or ATR, and is encoded by a gene located on human chromosome 1. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of SNM1B of human origin by WB, IP, IF and ELISA non cross-reactive with SNM1A or Snm1: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an internal region of SNM1B of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an internal region of SNM1B of human origin |
| Entrez Gene | 64858 |
|---|
Application
Western blot analysis of SNM1B expression in human cervix tissue extract (A) and HOS whole cell lysate (B).
Application
Western blot analysis of SNM1B expression in non-transfected: (A) and human SNM1B transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of SNM1B of human origin by WB, IP, IF and ELISA non cross-reactive with SNM1A or Snm1: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
