| Product Name | Calpain 10 Antibody (H-50) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-50 mapping at the N-terminus of Calpain 10 of human origin |
| Modification Notes | The CAPN10 (Calpain 10) gene encodes a ubiquitously expressed member of the Calpain-like cysteine protease family and shows association with type 2 diabetes Research suggests that Calpain 10 plays a role in an innovative pathway involved in the pathophysiology of diabetes, where Calpain-10 represents the third example of a protease contributing to the advancement of diabetes, the others being prohormone convertase-1 and prohormone-processing carboxypeptidase E, both of which are associated with diabetes and obesity. The CAPN10 human cDNA encodes a 672 amino-acid protein that shares 81.7% identity with the mouse ortholog, and analysis of human cDNA clones displays an intricate pattern of alternative splicing. CAPN10, which presumably plays a role in the regulation of insulin secretion, is thought to contain a signature of the effects of positive natural selection within its genetic sequence. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Calpain 10 isoforms A, B, C, D, E, F, G and H of mouse, rat and human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-50 mapping at the N-terminus of Calpain 10 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-50 mapping at the N-terminus of Calpain 10 of human origin |
| Application Notes | recommended for detection of Calpain 10 isoforms A, B, C, D, E, F, G and H of mouse, rat and human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
