| Product Name | DSCP1 Antibody (Q-23) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | recommended for detection of DSCP1 of human origin by WB, IP and ELISA |
| Modification Notes | DSCP1 (Damage-stimulated cytoplasmic protein 1), also known as TP53I13 (Tumor protein p53-inducible protein 13), is a 393 amino acid single-pass type I membrane protein that is ubiquitously expressed in normal adult tissues. Genotoxic stresses of adriamycin and/or ultraviolet beam irradiation lead to upregulation of DSCP1 in a p53-dependent manner. Overexpression of DSCP1 inhibits tumor cell growth, suggesting that it may act as a tumor suppressor. The gene encoding DSCP1 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPELISA |
| WB:1:500~1:2000 IP:1:100~1:500 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | recommended for detection of DSCP1 of human origin by WB IP and ELISA |
|---|---|
| Tissue Specificity | recommended for detection of DSCP1 of human origin by WB, IP and ELISA |
| Entrez Gene | 90313 |
|---|
| Application Notes | WB:1:500~1:2000 IP:1:100~1:500 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
