| Product Name | CREST Antibody (H-127) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 82-208 mapping within an internal region of CREST of human origin |
| Modification Notes | The calcium-responsive transactivator (CREST, SS18L1) protein localizes to nuclear bodies and is required for the normal development of neuronal dendritic trees. CREST contains a multifunctional domain (MFD), which mediates transcription transactivation, nuclear body targeting, and dimerization. CREST interacts with adenosine 3',5'-monophosphate (cAMP) response element-binding protein (CREB)-binding protein (CBP) to regulate neuronal morphogenesis. CREST exhibits ubiquitous expression, with lowest levels observed in the spleen. Mice with a targeted disruption of the Ss18l1 gene (Crest gene) are viable despite defects in cortical and hippocampal dendrite development. Cortical neurons from Crest-mutant mice are compromised in calcium-dependent dendritic growth, which leads to the conclusion that calcium activation of CREST-mediated transcription helps regulate neuronal morphogenesis. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of CREST of mouse, rat and human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 82-208 mapping within an internal region of CREST of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 82-208 mapping within an internal region of CREST of human origin |
| Entrez Gene | 26039 |
|---|
| Application Notes | recommended for detection of CREST of mouse, rat and human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
