Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human cervix and uterine tissue showing nuclear and cytoplasmic staining of squamouse epithelial cells at high magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.Application
Western blot analysis of RPESP expression in RPE-J (A), Y79 (B) and ARPE-19 (C) whole cell lysates and rat eye tissue extract (D).| Product Name | RPESP Antibody (D-20) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping near the C-terminus of RPESP of human origin |
| Modification Notes | RPE-spondin (RPESP) is a 264 amino acid protein encoded by a gene mapping to human chromosome 8. Made up of nearly 146 million bases, chromosome 8 encodes about 800 genes. Translocation of portions of chromosome 8 with amplifications of the c-Myc gene are found in some leukemias and lymphomas, and typically associated with a poor prognosis. Portions of chromosome 8 have been linked to schizophrenia and bipolar disorder. Trisomy 8, also known as Warkany syndrome 2, most often results in early miscarriage but is occasionally seen in a mosaic form in surviving patients who suffer to a varying degree from a number of symptoms including retarded mental and motor development, and certain facial and developmental defects. WRN is a DNA helicase encoded by chromosome 8 and shown defective in those with the early aging disorder Werner syndrome. Chromosome 8 is also associated with Pfeiffer syndrome, congenital hypothyroidism and Waardenburg syndrome. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFIHCELISA |
| recommended for detection of RPESP of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA also reactive with additional species, including canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping near the C-terminus of RPESP of human origin |
|---|---|
| Tissue Specificity | epitope mapping near the C-terminus of RPESP of human origin |
| Entrez Gene | 157869 |
|---|
Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human cervix and uterine tissue showing nuclear and cytoplasmic staining of squamouse epithelial cells at high magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.
Application
Western blot analysis of RPESP expression in RPE-J (A), Y79 (B) and ARPE-19 (C) whole cell lysates and rat eye tissue extract (D).| Application Notes | recommended for detection of RPESP of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA also reactive with additional species, including canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
