| Product Name | Nischarin Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1212-1504 mapping at the C-terminus of Nischarin of human origin |
| Modification Notes | Integrins play important roles in key cellular functions, including cytoskeletal organization, growth, survival, motility and gene expression regulation. Nischarin is a novel intracellular protein, that binds to the cytoplasmic domain of integrin å5/∫1 and interacts with various members of the PAK family of kinases. Nischarin binding to PAK1 inhibits the ability of PAK1 to phosphorylate substrates. When bound, this complex localizes to membrane ruffles which are involved in cell motility. Nischarin also acts as an antagonist of Rac function on cell movement and alters actin filament organization. These functions give Nischarin a possible role in cell migration regulation. Nischarin is a primarily cytoplasmic protein primarily expressed in kidney and brain. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Nischarin of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1212-1504 mapping at the C-terminus of Nischarin of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1212-1504 mapping at the C-terminus of Nischarin of human origin |
| Application Notes | recommended for detection of Nischarin of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
