Application
Western blot analysis of FREM2 expression in rat skeletal (A) and mouse embryo (B) tissue extracts.Application
Western blot analysis of FREM2 expression in C2C12 (A) and NIH/3T3 (B) whole cell lysates and mouse embryo tissue extract (C).| Product Name | FREM2 Antibody (S-18) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping within an extracellular domain of FREM2 of human origin |
| Modification Notes | FREM2 (FRAS1 related extracellular matrix protein 2) is a 3,169 amino acid single-pass type I membrane protein that localizes to the extracellular side of the cell membrane and contains five Calx-beta domains, as well as 12 CSPG repeats. Functioning as an extracellular matrix protein, FREM2 is required for the maintenance of skin and renal epithelia and is also thought to be involved in epidermal adhesion events. Defects or mutations in the gene encoding FREM2, which maps to human chromsome 13, are associated with Fraser syndrome, a multisystem malformation that is characterized by ear abnormalities, congenital heart defects and cutaneous syndactyly. FREM2 exists as multiple alternatively spliced isoforms. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of FREM2 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with family members FREM1 or FREM3 also reactive with additional species, including canine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an extracellular domain of FREM2 of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an extracellular domain of FREM2 of human origin |
| Entrez Gene | 341640 |
|---|
Application
Western blot analysis of FREM2 expression in rat skeletal (A) and mouse embryo (B) tissue extracts.
Application
Western blot analysis of FREM2 expression in C2C12 (A) and NIH/3T3 (B) whole cell lysates and mouse embryo tissue extract (C).| Application Notes | recommended for detection of FREM2 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with family members FREM1 or FREM3 also reactive with additional species, including canine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
