KLHL5, also known as kelch-like protein 5, is a 755 amino acid protein similar to the Drosophila kelch protein. Localized to the cytoskeleton, KLHL5 is expressed at higher levels in thyroid gland, adrenal gland and ovary and has lower expression in spinal chord, prostate, lymph node, trachea and testis. KLHL5 contains six kelch repeats and one BTB (POZ) domain. The BTB (broad complex, tramtrack and bric-a-brac) domain, also known as the POZ (Poxvirus and Zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function. KLHL5 is expressed as three isoforms produced by alternative splicing.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPELISA
recommended for detection of KLHL5 of human, rat and canine origin by WB, IP and ELISA