MAMLD1 (mastermind-like domain-containing protein 1), also known as CXorf6, CG1 or F18, is a 701 amino acid member of the mastermind family of proteins. Expressed in brain, heart and skeletal muscle, MAMLD1 co-localizes with MAML2 (Mastermind-like protein 2) to nuclear bodies and is thought to function as a transcriptional co-activator that enhances promoter function. Via its ability to promote transcription, MAMLD1 may regulate testosterone production, possibly playing a role in developmental events, such as spermatogenesis. Defects in the gene encoding MAMLD1 are the cause of X-linked hypospadias, a complex disorder in which the urethra opens on the central side of the penis. Multiple isoforms of MAMLD1 exist due to alternative splicing.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPELISA
recommended for detection of MAMLD1 of human origin by WB, IP and ELISA: