Application
Western blot analysis of PE-1 expression in HeLa whole cell lysate.| Product Name | PE-1 Antibody (H-172) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 142-313 mapping within an internal region of PE-1 of human origin |
| Modification Notes | PE-1 (PU-Ets related-1), also known as ETV3 (ETS translocation variant 3) or METS (Mitogenic Ets transcriptional suppressor), belongs to the ETS family of transcription factors and functions as a transcriptional repressor. ETS family members share a highly conserved DNA binding domain and play a role in growth factor pathways regulating proliferation and differentiation. PE-1 is ubiquitously expressed and localizes to the nucleus. Its expression can be induced by IL-10 via the STAT3 pathway suggesting that PE-1 contributes to the IL-10 downstream anti-inflammatory effects. During terminal cell differentiation, PE-1 plays a role in growth arrest by specifically repressing the target genes that are involved in Ras-dependent proliferation. The contributions of PE-1 to these anti-proliferative effects are heavily dependent on its interaction with Gemin3. Two PE-1 isoforms exist due to alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of PE-1 of human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 142-313 mapping within an internal region of PE-1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 142-313 mapping within an internal region of PE-1 of human origin |
| Entrez Gene | 2117 |
|---|
Application
Western blot analysis of PE-1 expression in HeLa whole cell lysate.| Application Notes | recommended for detection of PE-1 of human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
