| Product Name | ATF-7IP Antibody (M-113) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | ATF-7IP (Activating transcription factor 7-interacting protein 1, MBD1-containing chromatin-associated factor 1) is a 1,270 amino acid protein encoded by the human gene ATF7IP. ATF-7IP can both act as an activator or a repressor depending on the context. ATF-7IP functions as a recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. It mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. ATF-7IP is required to stimulate the histone methyltransferase activity of SETDB1 and it facilitates the conversion of dimethylated to trimethylated H3 'Lys-9'. The complex formed by ATF-7IP, MBD1 and SETDB1 also acts to couple DNA methylation to histone 'Lys-9' trimethylation. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of ATF-7IP of mouse and rat origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1058-1161 mapping near the C-terminus of ATF-7IP of mouse origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1058-1161 mapping near the C-terminus of ATF-7IP of mouse origin |
| Application Notes | recommended for detection of ATF-7IP of mouse and rat origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
