| Product Name | cytohesin-2 Antibody (H-37) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 31-67 mapping near the N-terminus of cytohesin-2 of human origin |
| Modification Notes | Cytohesin-2, also known as ARNO (ARF nucleotide-binding-site opener), is an ARF-1 guanine nucleotide exchange factor (GEF). ARF (ADP Ribosylation factor) proteins, a group within the RAS superfamily, are GTP-binding proteins central to the process of vesicle budding. Cytohesin-2 contains an N-terminal coiled-coil domain, a Sec 7 domain responsible for GDP/GTP exchange activity, and a C-terminal pleckstrin homology (PH) domain responsible for binding to PIP2. GEF activity of cytohesin-2 is enhanced by binding of the PH domain to phosphatidylinositol 4,5-bisphosphate which recruits cytohesin-2 to membranes. Cytohesin-2 is localized to the plasma membrane in mammalian cells and in vitro cytohesin-2 stimulates nucleotide exchange on ARF1 and ARF6. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of cytohesin-2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 31-67 mapping near the N-terminus of cytohesin-2 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 31-67 mapping near the N-terminus of cytohesin-2 of human origin |
| Entrez Gene | 9266 |
|---|
| Application Notes | recommended for detection of cytohesin-2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
