| Product Name | MtRPOL Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 841-1140 mapping near the C-terminus of MtRPOL of human origin |
| Modification Notes | The circular mitochondrial genome conrains 37 genes that encode the RNA constituents of the mitochondrial translational apparatus. Gene expression in mitochondria relies upon several nuclear genes that encode protein components required for transcription and translation of MtDNA-encoded genes, as well as protein and RNA components necessary for MtDNA replication. Mitochondrial RNA polymerase (MtRPOL) modulates gene expression in the mitochondria by providing the RNA primers for replication/initiation. It also participates in the maintenance and propagation of the mitochondrial genome. Genes involved in the replication and expression of MtRPOL may be candidates for various human disorders. MtRPOL consists of of 1,230 amino acid residues, the sequence of which demonstrates substantial homology with sequences corresponding to mitochondrial RNA polymerases from lower eukaryotes and to RNA polymerases from several bacteriophages. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISAGSChIP |
| recommended for detection of DNA-directed RNA Polymerase, mitochondrial precursor (MtRPOL) of mouse, rat and human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 841-1140 mapping near the C-terminus of MtRPOL of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 841-1140 mapping near the C-terminus of MtRPOL of human origin |
| Entrez Gene | 5442 |
|---|
| Application Notes | recommended for detection of DNA-directed RNA Polymerase, mitochondrial precursor (MtRPOL) of mouse, rat and human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
