Application
Western blot analysis of CCDC74A expression in non-transfected: (A) and human CCDC74A transfected: (B) 293T whole cell lysates.| Product Name | CCDC74A/B Antibody (E-13) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping within an internal region of CCDC74A of human origin |
| Modification Notes | The coiled-coil domain is a structural motif found in proteins that are involved in a diverse array of biological functions such as the regulation of gene expression, cell division, membrane fusion and drug extrusion and delivery. CCDC74A (Coiled-coil domain-containing protein 74A) and CCDC74B are 378 and 380 amino acid proteins, respectively, that each exist as two alternatively spliced isoforms. The genes encoding CCDC74A and CCDC74B both map to human chromosome 2, which houses over 1,400 genes and comprises nearly 8% of the human genome. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene, while the lipid metabolic disorder sitosterolemia is associated with defects in the ABCG5 and ABCG8 genes. Additionally, an extremely rare recessive genetic disorder, Alström syndrome, is caused by mutations in the ALMS1 gene, which maps to chromosome 2. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of CCDC74A and CCDC74B of human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an internal region of CCDC74A of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an internal region of CCDC74A of human origin |
| Entrez Gene | 90557 |
|---|
Application
Western blot analysis of CCDC74A expression in non-transfected: (A) and human CCDC74A transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of CCDC74A and CCDC74B of human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
