Application
Western blot analysis of AP-2δ expression in fetal muscle tissue extract.| Product Name | AP-2δ Antibody (J-18) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | raised against AP-2δ of human origin |
| Modification Notes | AP-2 transcription factor family members include AP-2å, AP-2∫, AP-2©, AP-2∂ and AP-2é, which specifically bind to DNA and regulate transcription of selected genes. AP-2 proteins contain a helix-span-helix motif at their C-terminus and a basic central region that, together, mediate DNA binding and dimerization. AP-2 family members have various roles in apoptosis, development, morphogenesis and cell-cycle control. AP-2∂, also known as TFAP2D or TFAP2BL1 (transcription factor AP-2 ∫-like 1), is a nuclear protein and is predominantly expressed in skeletal muscle, brain, small intestine, prostate, placenta and thymus. AP-2∂ binds to DNA as a dimer, associated either as a homodimer or as a heterodimer with other members of the AP-2 family. Distinct from other members of the family, AP-2∂ exhibits a different DNA sequence affinity and lacks the PY motif as well as other critical residues in its transactivation domain. This suggests that AP-2∂ may interact with a separate group of coactivators and transactivate genes differently than the other AP-2 proteins. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPELISA |
| recommended for detection of AP-2δ of mouse, rat, human, canine and zebrafish origin by WB, IP and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | raised against AP-2&delta of human origin |
|---|---|
| Tissue Specificity | raised against AP-2δ of human origin |
| Entrez Gene | 83741 |
|---|
Application
Western blot analysis of AP-2δ expression in fetal muscle tissue extract.| Application Notes | recommended for detection of AP-2δ of mouse, rat, human, canine and zebrafish origin by WB, IP and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
