Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human cerebellum tissue showing cytoplasmic and membrane staining of Purkinje cells and cells in molecular layer.| Product Name | Cacna2d2 Antibody (H-210) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-210 mapping at the N-terminus of Cacna2d2 of human origin |
| Modification Notes | CACNA2D2 is a gene coding for the protein calcium channel, voltage-dependent alpha2delta-2 (Cacna2d2), a regulatory subunit of the voltage dependent calcium channels. The protein interacts with alpha-1, beta and gamma subunits in a 1:1:1:1 ratio to form a channel mediating calcium influx. Protein expression occurs in the brain, heart, and other tissues, and is involved in central nervous system function. Disruptions of the CACNA2D2 gene may be involved in cerebellar ataxias and epileptic episodes in humans. The gene is localized to the tumor suppressor region of chromosome 3p21.3 in humans. Expression deficiency occurs in lung, breast and other cancers in humans. Part of a family of Alpha2/delta subunits involved in voltage-dependent calcium influx, Cacna2d2 shares 56% amino acid homology with the alpha2/delta-1 subunit, although they have different patterns of tissue expression. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFIHCELISA |
| recommended for detection of Cacna2d2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA also reactive with additional species, including porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-210 mapping at the N-terminus of Cacna2d2 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-210 mapping at the N-terminus of Cacna2d2 of human origin |
| Entrez Gene | 9254 |
|---|
Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human cerebellum tissue showing cytoplasmic and membrane staining of Purkinje cells and cells in molecular layer.| Application Notes | recommended for detection of Cacna2d2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA also reactive with additional species, including porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
